The most important problem concerning safety and medical feasibility of regular consumption of MCPs continues to be raised from your properly proven incontrovertible fact that the induction of collagen synthesis, predominantly assessed from the increased hydroxyproline levels, is usually connected with oxidative anxiety [28–30]. Moreover, MCPs of different origin have been demonstrated to activate innate immune response of macrophages and neutrophils by way of Toll-like receptor four, which leads to NADPH-oxidase (NOX4) activation and reactive oxygen species overproduction [31, 32].
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